The skills to pay the bills, 20 years ago, was the catch phrase that started the BioTechnical Institute of Maryland, Inc. (BTI) a non-profit located in Baltimore, MD. Margaret Penno, Ph.D, a researcher at Johns Hopkins Medical Institutions, had the idea that as the regions bioscience enterprise develops, everyone should be included. In other words, a rising tide raises all boats. Since its founding, BTI has trained entry-level lab technicians in R & D, production and bio-manufacturing positions at institutions like Johns Hopkins and at local biotech companies such as Emergent Biosolutions and Becton Dickenson to name a few employers of our graduates. Three assumptions are the foundations of BTI. The first is that there are good people that are under and unemployed that can do the work if trained properly. The second, is that those trained cannot afford the cost or time constraints of a college education. They need to work and BTI does not charge a tuition. And third, as biomanufacturing matures, college graduates will not want to do the repetitive critical tasks associated with “working on the factory floor.” As it turns out, these assumptions were correct.