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BEGIN:VEVENT
DTSTART;TZID=America/New_York:20240529T120000
DTEND;TZID=America/New_York:20240529T130000
DTSTAMP:20260415T074149
CREATED:20240627T164214Z
LAST-MODIFIED:20240627T164214Z
UID:4526-1716984000-1716987600@www.mdtechcouncil.com
SUMMARY:NCI Technology Opportunities Webinar: Proteolysis Targeting Chimeras (PROTACs) Targeting PIM Kinase for the Treatment of Cancer
DESCRIPTION:NEW DATE & NEW TIME: (Rescheduled from April 24th) \nRegister to attend a free NIH webinar. Attendees will learn about a new family of Proteolysis Targeting Chimeras (PROTACS) that selectively target Proviral Integration for the Moloney murine leukemia virus (PIM) kinases which have roles in cancer development and mediating resistance to radio and chemotherapy; and is overexpressed in multiple cancers. Several small molecule PIM kinase inhibitors have had minimal effect in suppressing cancer phenotypes due to the PIM kinase inhibitors promoting intrinsic resistance. By contrast\, these PIM targeted PROTACs suppress PIM kinase activity by completely degrading the PIM kinase proteins – intrinsic resistance is therefore avoided. \nThe inventors will discuss their newly developed PIM kinase-targeting PROTACs that promote the degradation of the PIM kinases in a prostate cancer cell model and increased chemo-sensitization. \n
URL:https://www.mdtechcouncil.com/membership/events/calendar/nci-technology-opportunities-webinar-proteolysis-targeting-chimeras-protacs-targeting-pim-kinase-for-the-treatment-of-cancer/
LOCATION:Virtual
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